Genetic modifiers of muscular dystrophy act on sarcolemmal resealing and recovery from injury.

Genetic modifiers of muscular dystrophy act on sarcolemmal resealing and recovery from injury.

Genetic disruption of the dystrophin complex produces muscular dystrophy characterized by a fragile muscle plasma membrane leading to excessive muscle degeneration. Two genetic modifiers of Duchenne Muscular Dystrophy implicate the transforming growth factor β (TGFβ) pathway, osteopontin encoded by...

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Bibliographic Details
Main Authors: Mattia Quattrocelli, Joanna Capote, Joyce C Ohiri, James L Warner, Andy H Vo, Judy U Earley, Michele Hadhazy, Alexis R Demonbreun, Melissa J Spencer, Elizabeth M McNally
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-10-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007070

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https://doi.org/10.1371/journal.pgen.1007070

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