Mutations in non-acid patch residues disrupt H2A.Z's association with chromatin through multiple mechanisms.

The incorporation of histone variants into nucleosomes is a critical mechanism for regulating essential DNA-templated processes and for establishing distinct chromatin architectures with specialised functions. H2A.Z is an evolutionarily conserved H2A variant that has diverse roles in transcriptional...

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Bibliographic Details
Main Authors: Thomas J Wood, Angela Thistlethwaite, Michael R Harris, Simon C Lovell, Catherine B Millar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3788105?pdf=render