Increased Protein <i>S</i>-Glutathionylation in Leber’s Hereditary Optic Neuropathy (LHON)

Increased Protein <i>S</i>-Glutathionylation in Leber’s Hereditary Optic Neuropathy (LHON)

Leber’s hereditary optic neuropathy (LHON, MIM#535000) is the most common form of inherited optic neuropathies and mitochondrial DNA-related diseases. The pathogenicity of mutations in genes encoding components of mitochondrial Complex I is well established, but the underlying pathomechanisms of the...

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Bibliographic Details
Main Authors: Lei Zhou, James Chun Yip Chan, Stephanie Chupin, Naig Gueguen, Valérie Desquiret-Dumas, Siew Kwan Koh, Jianguo Li, Yan Gao, Lu Deng, Chandra Verma, Roger W Beuerman, Eric Chun Yong Chan, Dan Milea, Pascal Reynier
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
Leber’s Hereditary Optic Neuropathy
LHON
<i>S</i>-glutathionylation
proteomics
mitochondrial Complex I
Online Access:https://www.mdpi.com/1422-0067/21/8/3027

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https://www.mdpi.com/1422-0067/21/8/3027

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