Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

In multiple sclerosis (MS), antigen-presenting cells inducing cytotoxic T cell response against mature oligodendrocytes remain to be identified. Here the authors show that oligodendrocyte precursors cross-present antigen taken up from mature oligodendrocytes, and are targeted by cytotoxic T cells in...

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Bibliographic Details
Main Authors: Leslie Kirby, Jing Jin, Jaime Gonzalez Cardona, Matthew D. Smith, Kyle A. Martin, Jingya Wang, Hayley Strasburger, Leyla Herbst, Maya Alexis, Jodi Karnell, Todd Davidson, Ranjan Dutta, Joan Goverman, Dwight Bergles, Peter A. Calabresi
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11638-3

Internet

https://doi.org/10.1038/s41467-019-11638-3

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