Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

In multiple sclerosis (MS), antigen-presenting cells inducing cytotoxic T cell response against mature oligodendrocytes remain to be identified. Here the authors show that oligodendrocyte precursors cross-present antigen taken up from mature oligodendrocytes, and are targeted by cytotoxic T cells in...

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Main Authors:	Leslie Kirby, Jing Jin, Jaime Gonzalez Cardona, Matthew D. Smith, Kyle A. Martin, Jingya Wang, Hayley Strasburger, Leyla Herbst, Maya Alexis, Jodi Karnell, Todd Davidson, Ranjan Dutta, Joan Goverman, Dwight Bergles, Peter A. Calabresi
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11638-3

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spelling	doaj-c2bdb6f697aa4aefb31caee253b40c562021-05-11T12:17:21ZengNature Publishing GroupNature Communications2041-17232019-08-0110112010.1038/s41467-019-11638-3Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelinationLeslie Kirby0Jing Jin1Jaime Gonzalez Cardona2Matthew D. Smith3Kyle A. Martin4Jingya Wang5Hayley Strasburger6Leyla Herbst7Maya Alexis8Jodi Karnell9Todd Davidson10Ranjan Dutta11Joan Goverman12Dwight Bergles13Peter A. Calabresi14Department of Neurology, Johns Hopkins School of MedicineDepartment of Neurology, Johns Hopkins School of MedicineDepartment of Neurology, Johns Hopkins School of MedicineDepartment of Neurology, Johns Hopkins School of MedicineDepartment of Neurology, Johns Hopkins School of MedicineMedImmune LLCDepartment of Neurology, Johns Hopkins School of MedicineDepartment of Neurology, Johns Hopkins School of MedicineDepartment of Neurology, Johns Hopkins School of MedicineMedImmune LLCMedImmune LLCDepartment of Neuroscience, Cleveland Clinic FoundationDepartment of Immunology, University of WashingtonSolomon H. Snyder Department of Neuroscience, Johns Hopkins School of MedicineDepartment of Neurology, Johns Hopkins School of MedicineIn multiple sclerosis (MS), antigen-presenting cells inducing cytotoxic T cell response against mature oligodendrocytes remain to be identified. Here the authors show that oligodendrocyte precursors cross-present antigen taken up from mature oligodendrocytes, and are targeted by cytotoxic T cells in cell culture and in an animal model of MS.https://doi.org/10.1038/s41467-019-11638-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Leslie Kirby Jing Jin Jaime Gonzalez Cardona Matthew D. Smith Kyle A. Martin Jingya Wang Hayley Strasburger Leyla Herbst Maya Alexis Jodi Karnell Todd Davidson Ranjan Dutta Joan Goverman Dwight Bergles Peter A. Calabresi
spellingShingle	Leslie Kirby Jing Jin Jaime Gonzalez Cardona Matthew D. Smith Kyle A. Martin Jingya Wang Hayley Strasburger Leyla Herbst Maya Alexis Jodi Karnell Todd Davidson Ranjan Dutta Joan Goverman Dwight Bergles Peter A. Calabresi Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination Nature Communications
author_facet	Leslie Kirby Jing Jin Jaime Gonzalez Cardona Matthew D. Smith Kyle A. Martin Jingya Wang Hayley Strasburger Leyla Herbst Maya Alexis Jodi Karnell Todd Davidson Ranjan Dutta Joan Goverman Dwight Bergles Peter A. Calabresi
author_sort	Leslie Kirby
title	Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
title_short	Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
title_full	Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
title_fullStr	Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
title_full_unstemmed	Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
title_sort	oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-08-01
description	In multiple sclerosis (MS), antigen-presenting cells inducing cytotoxic T cell response against mature oligodendrocytes remain to be identified. Here the authors show that oligodendrocyte precursors cross-present antigen taken up from mature oligodendrocytes, and are targeted by cytotoxic T cells in cell culture and in an animal model of MS.
url	https://doi.org/10.1038/s41467-019-11638-3
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Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

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