Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination
In multiple sclerosis (MS), antigen-presenting cells inducing cytotoxic T cell response against mature oligodendrocytes remain to be identified. Here the authors show that oligodendrocyte precursors cross-present antigen taken up from mature oligodendrocytes, and are targeted by cytotoxic T cells in...
Main Authors: | Leslie Kirby, Jing Jin, Jaime Gonzalez Cardona, Matthew D. Smith, Kyle A. Martin, Jingya Wang, Hayley Strasburger, Leyla Herbst, Maya Alexis, Jodi Karnell, Todd Davidson, Ranjan Dutta, Joan Goverman, Dwight Bergles, Peter A. Calabresi |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-11638-3 |
Similar Items
-
Quetiapine has an additive effect to triiodothyronine in inducing differentiation of oligodendrocyte precursor cells through induction of cholesterol biosynthesis.
by: Jaime Gonzalez Cardona, et al.
Published: (2019-01-01) -
Alteration of Synaptic Connectivity of Oligodendrocyte Precursor Cells Following Demyelination
by: Aurélia eSahel, et al.
Published: (2015-03-01) -
Cerebral cortex demyelination and oligodendrocyte precursor response to experimental autoimmune encephalomyelitis
by: Francesco Girolamo, et al.
Published: (2011-09-01) -
Automated in vivo Tracking of Cortical Oligodendrocytes
by: Yu Kang T. Xu, et al.
Published: (2021-04-01) -
The effect of glia-glia interactions on oligodendrocyte precursor cell biology during development and in demyelinating diseases
by: Diego eClemente, et al.
Published: (2013-12-01)