Misframed ubiquitin and impaired protein quality control; an early event in Alzheimer’s disease

Misframed ubiquitin and impaired protein quality control; an early event in Alzheimer’s disease

Aβ plaque formation is a prominent cellular hallmark of Alzheimer’s disease (AD). To date, immunization trials in AD patients have not been effective in terms of curing or ameliorating dementia. In addition, γ-secretase inhibitor strategies await clinical improvements in AD. These approaches were ba...

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Bibliographic Details
Main Authors: Romina Jozefa Gentier, Fred W. Van eLeeuwen
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
tau Proteins
neurodegeneration
amyloid precursor protein
Proteasome
mRNA surveillance
frameshift mutation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00047/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00047/full

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