Candida albicans β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages

Candida albicans β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages

β-Glucan derived from cell walls of Candida albicans is a potent immune modulator. It has been shown to induce trained immunity in monocytes via epigenetic and metabolic reprogramming and to protect from lethal sepsis if applied prior to infection. Since β-glucan-trained monocytes have not been clas...

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Bibliographic Details
Main Authors: Julia Leonhardt, Silke Große, Christian Marx, Fatina Siwczak, Sven Stengel, Tony Bruns, Reinhard Bauer, Michael Kiehntopf, David L. Williams, Zhao-Qi Wang, Alexander S. Mosig, Sebastian Weis, Michael Bauer, Regine Heller
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
β-glucan
Candida albicans
monocyte survival
monocyte to macrophage differentiation
trained immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02818/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02818/full

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