Iduronate-2-Sulfatase-Regulated Dermatan Sulfate Levels Potentiate the Invasion of Breast Cancer Epithelia through Collagen Matrix

Iduronate-2-Sulfatase-Regulated Dermatan Sulfate Levels Potentiate the Invasion of Breast Cancer Epithelia through Collagen Matrix

Cancer epithelia show elevation in levels of sulfated proteoglycans including dermatan sulfates (DS). The effect of increased DS on cancer cell behavior is still unclear. We hypothesized that decreased expression of the enzyme Iduronate-2-sulfatase (IDS) can lead to increased DS levels, which would...

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Bibliographic Details
Main Authors: Vishal Singh, Keshav Kumar Jha, Jyothsna K. M, Rekha V. Kumar, Varun Raghunathan, Ramray Bhat
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Journal of Clinical Medicine
Subjects:
dermatan sulfate
breast cancer
iduronate-2-sulfatase
Online Access:https://www.mdpi.com/2077-0383/8/10/1562

Internet

https://www.mdpi.com/2077-0383/8/10/1562

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