Iduronate-2-Sulfatase-Regulated Dermatan Sulfate Levels Potentiate the Invasion of Breast Cancer Epithelia through Collagen Matrix
Cancer epithelia show elevation in levels of sulfated proteoglycans including dermatan sulfates (DS). The effect of increased DS on cancer cell behavior is still unclear. We hypothesized that decreased expression of the enzyme Iduronate-2-sulfatase (IDS) can lead to increased DS levels, which would...
Main Authors: | Vishal Singh, Keshav Kumar Jha, Jyothsna K. M, Rekha V. Kumar, Varun Raghunathan, Ramray Bhat |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-09-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/8/10/1562 |
Similar Items
-
Molecular investigations of iduronate-2-sulfatase mutants.
Published: (2006) -
Comparative Study of Two Chondroitin Sulfate/Dermatan Sulfate 4-O-Sulfatases With High Identity
by: Shumin Wang, et al.
Published: (2019-06-01) -
Relationships of iduronic acid-2-sulfatase with metastasis and prognosis of colorectal cancer
by: YANG Zeyu, et al.
Published: (2019-09-01) -
A study of the relationship between clinical phenotypes and plasma iduronate-2-sulfatase enzyme activities in Hunter syndrome patients
by: Ok Jeong Lee, et al.
Published: (2012-03-01) -
High-Throughput Liquid Chromatography–Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II
by: Junhua Wang, et al.
Published: (2020-07-01)