The time-dependent effects of St John’s wort on cytochrome P450, uridine diphosphate-glucuronosyltransferase, glutathione S-transferase, and NAD(P)H-quinone oxidoreductase in mice

The time-dependent effects of St John’s wort on cytochrome P450, uridine diphosphate-glucuronosyltransferase, glutathione S-transferase, and NAD(P)H-quinone oxidoreductase in mice

Hypericum perforatum [St. John’s wort (SJW)] is known to cause a drug interaction with the substrates of cytochrome P450 (P450, CYP) isoforms, mainly CYP3A. This study aims to determine the dose response and time course of the effects of SJW extract on P450s, UDP-glucuronosyltransferase (UGT), gluta...

Full description

Bibliographic Details
Main Authors: Jin-Fu Yang, Yue-Rong Liu, Chiung-Chiao Huang, Yune-Fang Ueng
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Journal of Food and Drug Analysis
Subjects:
cytochrome P450 2C
cytochrome P450 3A
Hypericum perforatum
liver
kidney
Online Access:http://www.sciencedirect.com/science/article/pii/S1021949817300443

Internet

http://www.sciencedirect.com/science/article/pii/S1021949817300443

Similar Items