Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans
Abstract Background The histamine H3 receptor is regarded as a drug target for cognitive impairments in psychiatric disorders. H3 receptors are expressed in neocortical areas, including the prefrontal cortex, the key region of cognitive functions such as working memory. However, the role of prefront...
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doaj-c2cb963f0ae84c61975edfcfff3c44602020-11-24T21:21:02ZengSpringerOpenEJNMMI Research2191-219X2018-06-01811410.1186/s13550-018-0406-4Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humansTakehito Ito0Yasuyuki Kimura1Chie Seki2Masanori Ichise3Keita Yokokawa4Kazunori Kawamura5Hidehiko Takahashi6Makoto Higuchi7Ming-Rong Zhang8Tetsuya Suhara9Makiko Yamada10Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and TechnologyDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and TechnologyDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and TechnologyDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and TechnologyDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and TechnologyDepartment of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and TechnologyDepartment of Psychiatry, Graduate School of Medicine, Kyoto UniversityDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and TechnologyDepartment of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and TechnologyDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and TechnologyDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and TechnologyAbstract Background The histamine H3 receptor is regarded as a drug target for cognitive impairments in psychiatric disorders. H3 receptors are expressed in neocortical areas, including the prefrontal cortex, the key region of cognitive functions such as working memory. However, the role of prefrontal H3 receptors in working memory has not yet been clarified. Therefore, using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) techniques, we aimed to investigate the association between the neural activity of working memory and the density of H3 receptors in the prefrontal cortex. Findings Ten healthy volunteers underwent both fMRI and PET scans. The N-back task was used to assess the neural activities related to working memory. H3 receptor density was measured with the selective PET radioligand [11C] TASP457. The neural activity of the right dorsolateral prefrontal cortex during the performance of the N-back task was negatively correlated with the density of H3 receptors in this region. Conclusions Higher neural activity of working memory was associated with lower H3 receptor density in the right dorsolateral prefrontal cortex. This finding elucidates the role of H3 receptors in working memory and indicates the potential of H3 receptors as a therapeutic target for the cognitive impairments associated with neuropsychiatric disorders.http://link.springer.com/article/10.1186/s13550-018-0406-4Histamine H3 receptorWorking memoryPETfMRI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takehito Ito Yasuyuki Kimura Chie Seki Masanori Ichise Keita Yokokawa Kazunori Kawamura Hidehiko Takahashi Makoto Higuchi Ming-Rong Zhang Tetsuya Suhara Makiko Yamada |
spellingShingle |
Takehito Ito Yasuyuki Kimura Chie Seki Masanori Ichise Keita Yokokawa Kazunori Kawamura Hidehiko Takahashi Makoto Higuchi Ming-Rong Zhang Tetsuya Suhara Makiko Yamada Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans EJNMMI Research Histamine H3 receptor Working memory PET fMRI |
author_facet |
Takehito Ito Yasuyuki Kimura Chie Seki Masanori Ichise Keita Yokokawa Kazunori Kawamura Hidehiko Takahashi Makoto Higuchi Ming-Rong Zhang Tetsuya Suhara Makiko Yamada |
author_sort |
Takehito Ito |
title |
Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans |
title_short |
Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans |
title_full |
Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans |
title_fullStr |
Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans |
title_full_unstemmed |
Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans |
title_sort |
histamine h3 receptor density is negatively correlated with neural activity related to working memory in humans |
publisher |
SpringerOpen |
series |
EJNMMI Research |
issn |
2191-219X |
publishDate |
2018-06-01 |
description |
Abstract Background The histamine H3 receptor is regarded as a drug target for cognitive impairments in psychiatric disorders. H3 receptors are expressed in neocortical areas, including the prefrontal cortex, the key region of cognitive functions such as working memory. However, the role of prefrontal H3 receptors in working memory has not yet been clarified. Therefore, using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) techniques, we aimed to investigate the association between the neural activity of working memory and the density of H3 receptors in the prefrontal cortex. Findings Ten healthy volunteers underwent both fMRI and PET scans. The N-back task was used to assess the neural activities related to working memory. H3 receptor density was measured with the selective PET radioligand [11C] TASP457. The neural activity of the right dorsolateral prefrontal cortex during the performance of the N-back task was negatively correlated with the density of H3 receptors in this region. Conclusions Higher neural activity of working memory was associated with lower H3 receptor density in the right dorsolateral prefrontal cortex. This finding elucidates the role of H3 receptors in working memory and indicates the potential of H3 receptors as a therapeutic target for the cognitive impairments associated with neuropsychiatric disorders. |
topic |
Histamine H3 receptor Working memory PET fMRI |
url |
http://link.springer.com/article/10.1186/s13550-018-0406-4 |
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