The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway

The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway

Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes. In this study we describe multi-organ developmental abnormalities in the Tmem67tm1Dgen/H1 knock...

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Bibliographic Details
Main Authors: Zakia A. Abdelhamed, Subaashini Natarajan, Gabrielle Wheway, Christopher F. Inglehearn, Carmel Toomes, Colin A. Johnson, Daniel J. Jagger
Format: Article
Language:English
Published: The Company of Biologists 2015-06-01
Series:Disease Models & Mechanisms
Subjects:
TMEM67
Meckelin
MKS3
Wnt signalling
Planar cell polarity
PCP
Stereocilia
Kinocilia
Primary cilia
Hair bundle
Ciliopathy
Online Access:http://dmm.biologists.org/content/8/6/527

Internet

http://dmm.biologists.org/content/8/6/527

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