<i>PTEN</i> Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine?

<i>PTEN</i> Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine?

Alterations in the tumor suppressor<b> </b>phosphatase and tensin homolog (<i>PTEN</i>) occur in a substantial proportion of solid tumors. These events drive tumorigenesis and tumor progression. Given its central role as a downregulator of the phosphoinositide 3-kinase (PI3K)...

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Bibliographic Details
Main Authors: Nicola Fusco, Elham Sajjadi, Konstantinos Venetis, Gabriella Gaudioso, Gianluca Lopez, Chiara Corti, Elena Guerini Rocco, Carmen Criscitiello, Umberto Malapelle, Marco Invernizzi
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Genes
Subjects:
PTEN
tumor suppressor
PI3K/Akt
cancer
solid tumors
tumor immune microenvironment
Online Access:https://www.mdpi.com/2073-4425/11/7/719

Internet

https://www.mdpi.com/2073-4425/11/7/719

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