Molecular regulatory mechanisms of osteoclastogenesis through cytoprotective enzymes

It has been reported that reactive oxygen species (ROS), such as hydrogen peroxide and superoxide, take part in osteoclast differentiation as intra-cellular signaling molecules. The current assumed signaling cascade from RANK to ROS production is RANK, TRAF6, Rac1, and then Nox. The target molecules...

Full description

Bibliographic Details
Main Authors: Hiroyuki Kanzaki, Fumiaki Shinohara, Itohiya Kanako, Yuuki Yamaguchi, Sari Fukaya, Yutaka Miyamoto, Satoshi Wada, Yoshiki Nakamura
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Redox Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716300052