Nitro-Oleic Acid (NO<sub>2</sub>-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis

Nitro-Oleic Acid (NO<sub>2</sub>-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis

Nitro-oleic acid (NO<sub>2</sub>-OA), a nitric oxide (NO)- and nitrite (NO<sub>2</sub><sup>−</sup>)-derived electrophilic fatty acid metabolite, displays anti-inflammatory and anti-fibrotic signaling actions and therapeutic benefit in murine models of ischemia-rep...

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Bibliographic Details
Main Authors: Simon Braumann, Wibke Schumacher, Nam Gyu Im, Felix Sebastian Nettersheim, Dennis Mehrkens, Senai Bokredenghel, Alexander Hof, Richard Julius Nies, Christoph Adler, Holger Winkels, Ralph Knöll, Bruce A. Freeman, Volker Rudolph, Anna Klinke, Matti Adam, Stephan Baldus, Martin Mollenhauer, Simon Geißen
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
nitro-oleic acid
dilated cardiomyopathy
muscle LIM protein
myocardial fibrosis
TGFβ
alpha smooth muscle actin
Online Access:https://www.mdpi.com/1422-0067/22/16/9052

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https://www.mdpi.com/1422-0067/22/16/9052

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