Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice.

Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice.

Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is the most common inherited disorder of mitochondrial fatty acid beta-oxidation in humans. To better understand the pathogenesis of this disease, we developed a mouse model for MCAD deficiency (MCAD-/-) by gene targeting in embryonic stem (ES) c...

Full description

Bibliographic Details
Main Authors: Ravi J Tolwani, Doug A Hamm, Liqun Tian, J Daniel Sharer, Jerry Vockley, Piero Rinaldo, Dietrich Matern, Trenton R Schoeb, Philip A Wood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2005-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1189074?pdf=render

Internet

http://europepmc.org/articles/PMC1189074?pdf=render

Similar Items