DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces

DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces

DYT1 dystonia is a neurological movement disorder that is caused by a loss-of-function mutation in the DYT1/TOR1A gene, which encodes torsinA, a conserved luminal ATPases-associated with various cellular activities (AAA+) protein. TorsinA is required for the assembly of functional linker of nucleosk...

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Bibliographic Details
Main Authors: Navjot Kaur Gill, Chau Ly, Paul H. Kim, Cosmo A. Saunders, Loren G. Fong, Stephen G. Young, G. W. Gant Luxton, Amy C. Rowat
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
torsinA
LINC complex
mechanotype
cell mechanical properties
nuclear envelope
lamins
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00103/full

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https://www.frontiersin.org/article/10.3389/fcell.2019.00103/full

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