Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat
Recent evidence implicates adult hippocampal neurogenesis in regulating behavioral and physiologic responses to stress. Hippocampal neurogenesis occurs across the lifespan, however the rate of cell birth is up to 300% higher in adolescent mice compared to adults. Adolescence is a sensitive period in...
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doaj-c2e2266f4baf4a02b1fda384260d240b2020-11-25T00:26:16ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532014-08-01810.3389/fnbeh.2014.00289105070Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeatGreer S Kirshenbaum0Sophie Rose Lieberman1Tamara J Briner2Eduardo David Leonardo3Alex eDranovsky4New York State Psychiatric Institute, Columbia UniversityNew York State Psychiatric Institute, Columbia UniversityNew York State Psychiatric Institute, Columbia UniversityNew York State Psychiatric Institute, Columbia UniversityNew York State Psychiatric Institute, Columbia UniversityRecent evidence implicates adult hippocampal neurogenesis in regulating behavioral and physiologic responses to stress. Hippocampal neurogenesis occurs across the lifespan, however the rate of cell birth is up to 300% higher in adolescent mice compared to adults. Adolescence is a sensitive period in development where emotional circuitry and stress reactivity undergo plasticity establishing life-long set points. Therefore neurogenesis occurring during adolescence may be particularly important for emotional behavior. However, little is known about the function of hippocampal neurons born during adolescence. In order to assess the contribution of neurons born in adolescence to the adult stress response and depression-related behavior, we transiently reduced cell proliferation either during adolescence, or during adulthood in GFAP-Tk mice. We found that the intervention in adolescence did not change baseline behavioral responses in the forced swim test, sucrose preference test or social affiliation test, and did not change corticosterone responses to an acute stressor. However following chronic social defeat, adult mice with reduced adolescent neurogenesis showed a resilient phenotype. A similar transient reduction in adult neurogenesis did not affect depression-like behaviors or stress induced corticosterone. Our study demonstrates that hippocampal neurons born during adolescence, but not in adulthood are important to confer susceptibility to chronic social defeat.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00289/fullAdolescentNeurogenesisGFAP-Tkchronic social defeatresilient |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Greer S Kirshenbaum Sophie Rose Lieberman Tamara J Briner Eduardo David Leonardo Alex eDranovsky |
spellingShingle |
Greer S Kirshenbaum Sophie Rose Lieberman Tamara J Briner Eduardo David Leonardo Alex eDranovsky Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat Frontiers in Behavioral Neuroscience Adolescent Neurogenesis GFAP-Tk chronic social defeat resilient |
author_facet |
Greer S Kirshenbaum Sophie Rose Lieberman Tamara J Briner Eduardo David Leonardo Alex eDranovsky |
author_sort |
Greer S Kirshenbaum |
title |
Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat |
title_short |
Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat |
title_full |
Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat |
title_fullStr |
Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat |
title_full_unstemmed |
Adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat |
title_sort |
adolescent but not adult-born neurons are critical for susceptibility to chronic social defeat |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Behavioral Neuroscience |
issn |
1662-5153 |
publishDate |
2014-08-01 |
description |
Recent evidence implicates adult hippocampal neurogenesis in regulating behavioral and physiologic responses to stress. Hippocampal neurogenesis occurs across the lifespan, however the rate of cell birth is up to 300% higher in adolescent mice compared to adults. Adolescence is a sensitive period in development where emotional circuitry and stress reactivity undergo plasticity establishing life-long set points. Therefore neurogenesis occurring during adolescence may be particularly important for emotional behavior. However, little is known about the function of hippocampal neurons born during adolescence. In order to assess the contribution of neurons born in adolescence to the adult stress response and depression-related behavior, we transiently reduced cell proliferation either during adolescence, or during adulthood in GFAP-Tk mice. We found that the intervention in adolescence did not change baseline behavioral responses in the forced swim test, sucrose preference test or social affiliation test, and did not change corticosterone responses to an acute stressor. However following chronic social defeat, adult mice with reduced adolescent neurogenesis showed a resilient phenotype. A similar transient reduction in adult neurogenesis did not affect depression-like behaviors or stress induced corticosterone. Our study demonstrates that hippocampal neurons born during adolescence, but not in adulthood are important to confer susceptibility to chronic social defeat. |
topic |
Adolescent Neurogenesis GFAP-Tk chronic social defeat resilient |
url |
http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00289/full |
work_keys_str_mv |
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