Updates on the Role of Molecular Alterations and NOTCH Signalling in the Development of Neuroendocrine Neoplasms

Updates on the Role of Molecular Alterations and NOTCH Signalling in the Development of Neuroendocrine Neoplasms

Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of rare malignancies, mainly originating from hormone-secreting cells, which are widespread in human tissues. The identification of mutations in ATRX/DAXX genes in sporadic NENs, as well as the high burden of mutations scattered througho...

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Bibliographic Details
Main Authors: Claudia von Arx, Monica Capozzi, Elena López-Jiménez, Alessandro Ottaiano, Fabiana Tatangelo, Annabella Di Mauro, Guglielmo Nasti, Maria Lina Tornesello, Salvatore Tafuto
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Journal of Clinical Medicine
Subjects:
neuroendocrine neoplasms
NOTCH
cancer-driven genes
mutational mechanism
germline mutations
small cell lung carcinoma
pancreatic NET
small bowel NET
medullary thyroid carcinoma
malignant castration-resistant prostatic cells
Online Access:https://www.mdpi.com/2077-0383/8/9/1277

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https://www.mdpi.com/2077-0383/8/9/1277

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