Natural killer cells generated from cord blood hematopoietic progenitor cells efficiently target bone marrow-residing human leukemia cells in NOD/SCID/IL2Rg(null) mice.

Natural killer cells generated from cord blood hematopoietic progenitor cells efficiently target bone marrow-residing human leukemia cells in NOD/SCID/IL2Rg(null) mice.

Natural killer (NK) cell-based adoptive immunotherapy is an attractive adjuvant treatment option for patients with acute myeloid leukemia. Recently, we reported a clinical-grade, cytokine-based culture method for the generation of NK cells from umbilical cord blood (UCB) CD34⁺ hematopoietic progenit...

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Bibliographic Details
Main Authors: Jeannette Cany, Anniek B van der Waart, Marleen Tordoir, Gerben M Franssen, Basav N Hangalapura, Jolanda de Vries, Otto Boerman, Nicolaas Schaap, Robbert van der Voort, Jan Spanholtz, Harry Dolstra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3673996?pdf=render

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http://europepmc.org/articles/PMC3673996?pdf=render

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