Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis

Mammary epithelial stem cells are vital to tissue expansion and remodeling during various phases of postnatal mammary development. Basal mammary epithelial cells are enriched in Wnt-responsive cells and can reconstitute cleared mammary fat pads upon transplantation into mice. Lgr5 is a Wnt-regulate...

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Bibliographic Details
Main Authors: Vicki Plaks, Audrey Brenot, Devon A. Lawson, Jelena R. Linnemann, Eline C. Van Kappel, Karren C. Wong, Frederic de Sauvage, Ophir D. Klein, Zena Werb
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713000041