Calcium Influx Inhibition is Involved in the Hypotensive and Vasorelaxant Effects Induced by Yangambin

Calcium Influx Inhibition is Involved in the Hypotensive and Vasorelaxant Effects Induced by Yangambin

The pharmacological effects on the cardiovascular system of yangambin, a lignan isolated from Ocotea duckei Vattimo (Lauraceae), were studied in rats using combined functional and biochemical approaches. In non-anaesthetized rats, yangambin (1, 5, 10, 20, 30 mg/kg, i.v.) induced hypotension (−3.5 ±...

Full description

Bibliographic Details
Main Authors: Islania Giselia Albuquerque Araújo, Darizy Flávia Silva, Maria do Carmo de Alustau, Katy Lísias Gondim Dias, Karla Veruska Marques Cavalcante, Robson Cavalcante Veras, José Maria Barbosa-Filho, Mario dos Anjos Neto, Lusiane Maria Bendhack, Nadja de Azevedo Correia, Isac Almeida de Medeiros
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Molecules
Subjects:
lignan
yangambin
mesenteric artery
vasodilation
calcium influx
Online Access:http://www.mdpi.com/1420-3049/19/5/6863

Internet

http://www.mdpi.com/1420-3049/19/5/6863

Similar Items