Development and Validation of a Chiral Liquid Chromatographic Assay for Enantiomeric Separation and Quantification of Verapamil in Rat Plasma: Stereoselective Pharmacokinetic Application

Development and Validation of a Chiral Liquid Chromatographic Assay for Enantiomeric Separation and Quantification of Verapamil in Rat Plasma: Stereoselective Pharmacokinetic Application

A novel, fast and sensitive enantioselective HPLC assay with a new core–shell isopropyl carbamate cyclofructan 6 (superficially porous particle, SPP) chiral column (LarihcShell-P, LSP) was developed and validated for the enantiomeric separation and quantification of verapamil (VER) in rat plasma. Th...

Full description

Bibliographic Details
Main Authors: Mostafa S. Mohammed, Mohamed M. Hefnawy, Abdulrhman A. Al-Majed, Haitham K. Alrabiah, Nasser A. Algrain, Ahmad J. Obaidullah, Abdulmalik S. Altamimi, Yousef A. Bin Jardan, Abdullah M. Al-Hossaini
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
verapamil enantiomers
core–shell chiral column
chiral HPLC
rat plasma
stereoselective pharmacokinetics
Online Access:https://www.mdpi.com/1420-3049/26/7/2091

Internet

https://www.mdpi.com/1420-3049/26/7/2091

Similar Items