Catalytic mechanism of the tyrosinase reaction toward the Tyr98 residue in the caddie protein.

Catalytic mechanism of the tyrosinase reaction toward the Tyr98 residue in the caddie protein.

Tyrosinase (EC 1.14.18.1), a copper-containing monooxygenase, catalyzes the conversion of phenol to the corresponding ortho-quinone. The Streptomyces tyrosinase is generated as a complex with a "caddie" protein that facilitates the transport of two copper ions into the active center. In ou...

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Bibliographic Details
Main Authors: Yasuyuki Matoba, Shogo Kihara, Naohiko Bando, Hironari Yoshitsu, Miyuki Sakaguchi, Kure'e Kayama, Sachiko Yanagisawa, Takashi Ogura, Masanori Sugiyama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000077

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https://doi.org/10.1371/journal.pbio.3000077

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