Endothelial Focal Adhesions Are Functional Obstacles for Leukocytes During Basolateral Crawling

Endothelial Focal Adhesions Are Functional Obstacles for Leukocytes During Basolateral Crawling

An inflammatory response requires leukocytes to migrate from the circulation across the vascular lining into the tissue to clear the invading pathogen. Whereas a lot of attention is focused on how leukocytes make their way through the endothelial monolayer, it is less clear how leukocytes migrate un...

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Bibliographic Details
Main Authors: Janine J. G. Arts, Eike K. Mahlandt, Lilian Schimmel, Max L. B. Grönloh, Sanne van der Niet, Bart J. A. M. Klein, Mar Fernandez-Borja, Daphne van Geemen, Stephan Huveneers, Jos van Rijssel, Joachim Goedhart, Jaap D. van Buul
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
transmigration
focal adhesions
small GTPase
RhoJ
Tiam1
endothelium
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.667213/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.667213/full

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