The Performance of Gene Expression Signature-Guided Drug–Disease Association in Different Categories of Drugs and Diseases

The Performance of Gene Expression Signature-Guided Drug–Disease Association in Different Categories of Drugs and Diseases

A gene expression signature (GES) is a group of genes that shows a unique expression profile as a result of perturbations by drugs, genetic modification or diseases on the transcriptional machinery. The comparisons between GES profiles have been used to investigate the relationships between drugs, t...

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Bibliographic Details
Main Authors: Xiguang Qi, Mingzhe Shen, Peihao Fan, Xiaojiang Guo, Tianqi Wang, Ning Feng, Manling Zhang, Robert A. Sweet, Levent Kirisci, Lirong Wang
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molecules
Subjects:
gene expression signature
drug repositioning approaches
RNA expression regulation
Online Access:https://www.mdpi.com/1420-3049/25/12/2776

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