Lys694Arg polymorphism leads to blunted responses to LPS by interfering TLR4 with recruitment of MyD88
TLR4 polymorphisms such as Asp299Gly and Thr399Ile related to Gram-negative sepsis have been reported to result in significantly blunted responsiveness to LPS. Our study group previously screened other TLR4 polymorphic variants by checking the NF-κB activation in comparison to wild type (WT) TLR4 in...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-08-01
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| Series: | Innate Immunity |
| Online Access: | https://doi.org/10.1177/1753425920927479 |