Prophylactic application of CpG oligonucleotides augments the early host response and confers protection in acute melioidosis.

Prophylactic application of CpG oligonucleotides augments the early host response and confers protection in acute melioidosis.

Prophylactic administration of CpG oligodeoxynucleotides (CpG ODNs) is known to confer protection against lethal sepsis caused by Burkholderia pseudomallei in the mouse model. The mechanisms whereby CpG regulates the innate immune response to provide protection against B. pseudomallei, however, are...

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Bibliographic Details
Main Authors: Barbara M Judy, Katherine Taylor, Arpaporn Deeraksa, R Katie Johnston, Janice J Endsley, Sudhamathi Vijayakumar, Judith F Aronson, D Mark Estes, Alfredo G Torres
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3309019?pdf=render

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http://europepmc.org/articles/PMC3309019?pdf=render

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