The anti-scar effects of basic fibroblast growth factor on the wound repair in vitro and in vivo.

Hypertrophic scars (HTS) and keloids are challenging problems. Their pathogenesis results from an overproduction of fibroblasts and excessive deposition of collagen. Studies suggest a possible anti-scarring effect of basic fibroblast growth factor (bFGF) during wound healing, but the precise mechani...

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Main Authors: Hong-Xue Shi, Cai Lin, Bei-Bei Lin, Zhou-Guang Wang, Hong-Yu Zhang, Fen-Zan Wu, Yi Cheng, Li-Jun Xiang, Di-Jiong Guo, Xu Luo, Guo-You Zhang, Xiao-Bing Fu, Saverio Bellusci, Xiao-Kun Li, Jian Xiao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3615060?pdf=render