Spectroscopic Study of Cytosine Methylation Effect on Thermodynamics of DNA Duplex Containing CpG Motif

Effect of cytosine methylation on DNA duplexes was studied by using a model system of three self-complementary DNA octamers containing central CpG motif surrounded by a couple of AT base pairs, CAACGTTG, CATCGATG, and CTTCGAAG, and their analogues with the central cytosine methylated at C5 position....

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Bibliographic Details
Main Authors: Václav Římal, Ondřej Socha, Josef Štěpánek, Helena Štěpánková
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Journal of Spectroscopy
Online Access:http://dx.doi.org/10.1155/2015/842810