DDR1 Affects Metabolic Reprogramming in Breast Cancer Cells by Cross-Talking to the Insulin/IGF System

DDR1 Affects Metabolic Reprogramming in Breast Cancer Cells by Cross-Talking to the Insulin/IGF System

The insulin receptor isoform A (IR-A), a dual receptor for insulin and IGF2, plays a role in breast cancer (BC) progression and metabolic reprogramming. Notably, discoidin domain receptor 1 (DDR1), a collagen receptor often dysregulated in cancer, is involved in a functional crosstalk and feed forwa...

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Bibliographic Details
Main Authors: Veronica Vella, Marika Giuliano, Maria Luisa Nicolosi, Maria Giovanna Majorana, Małgorzata Anna Marć, Maria Grazia Muoio, Andrea Morrione, Marcello Maggiolini, Rosamaria Lappano, Ernestina Marianna De Francesco, Antonino Belfiore
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomolecules
Subjects:
discoidin domain receptor 1 (DDR1)
metabolic reprogramming
tumor metabolism
insulin
hyperinsulinemia
insulin receptor (IR)
Online Access:https://www.mdpi.com/2218-273X/11/7/926

Internet

https://www.mdpi.com/2218-273X/11/7/926

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