Evaluation of D-isomers of 4-borono-2-18F-fluoro-phenylalanine and O-11C-methyl-tyrosine as brain tumor imaging agents: a comparative PET study with their L-isomers in rat brain glioma

Evaluation of D-isomers of 4-borono-2-18F-fluoro-phenylalanine and O-11C-methyl-tyrosine as brain tumor imaging agents: a comparative PET study with their L-isomers in rat brain glioma

Abstract Background The potential of the D-isomerization of 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) to improve its target tumor to non-target normal brain tissue ratio (TBR) was evaluated in rat brain glioma and compared with those of L- and D-11C-methyl-tyrosine (11C-CMT). The L- or D-isomer...

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Bibliographic Details
Main Authors: Masakatsu Kanazawa, Shingo Nishiyama, Fumio Hashimoto, Takeharu Kakiuchi, Hideo Tsukada
Format: Article
Language:English
Published: SpringerOpen 2018-06-01
Series:EJNMMI Research
Subjects:
Boron neutron capture therapy
D-isomer
18F-FBPA
11C-CMT
Glioma
Online Access:http://link.springer.com/article/10.1186/s13550-018-0404-6

Internet

http://link.springer.com/article/10.1186/s13550-018-0404-6

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