A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans

Intermittent fasting is one of the most effective dietary restriction regimens that extend life span in C. elegans and mammals. Fasting-stimulus responses are key to the longevity response; however, the mechanisms that sense and transduce the fasting stimulus remain largely unknown. Through a compr...

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Main Authors: Masaharu Uno, Sakiko Honjoh, Mitsuhiro Matsuda, Haruka Hoshikawa, Saya Kishimoto, Tomohito Yamamoto, Miki Ebisuya, Takuya Yamamoto, Kunihiro Matsumoto, Eisuke Nishida
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713000053