Characterization of Effectiveness in Concerted <i>I</i><sub>h</sub> Inhibition and <i>I</i><sub>K(Ca)</sub> Stimulation by Pterostilbene (Trans-3,5-dimethoxy-4′-hydroxystilbene), a Stilbenoid

Characterization of Effectiveness in Concerted <i>I</i><sub>h</sub> Inhibition and <i>I</i><sub>K(Ca)</sub> Stimulation by Pterostilbene (Trans-3,5-dimethoxy-4′-hydroxystilbene), a Stilbenoid

Pterostilbene (PTER), a natural dimethylated analog of resveratrol, has been demonstrated to produce anti-neoplastic or neuroprotective actions. However, how and whether this compound can entail any perturbations on ionic currents in electrically excitable cells remains unknown. In whole-cell curren...

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Bibliographic Details
Main Authors: Edmund Cheung So, Zi-Han Gao, Shun Yao Ko, Sheng-Nan Wu
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
pterostilbene (trans-3,5-dimethoxy-4′-hydroxystilbene)
hyperpolarization-activated cation current
ca<sup>2+</sup>-activated k<sup>+</sup> current
large-conductance ca<sup>2+</sup>-activated k<sup>+</sup> channel
pituitary cell
hippocampal neuron
Online Access:https://www.mdpi.com/1422-0067/21/1/357

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https://www.mdpi.com/1422-0067/21/1/357

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