Trans-synaptic spread of tau pathology in vivo.

Trans-synaptic spread of tau pathology in vivo.

Tauopathy in the brain of patients with Alzheimer's disease starts in the entorhinal cortex (EC) and spreads anatomically in a defined pattern. To test whether pathology initiating in the EC spreads through the brain along synaptically connected circuits, we have generated a transgenic mouse mo...

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Bibliographic Details
Main Authors: Li Liu, Valerie Drouet, Jessica W Wu, Menno P Witter, Scott A Small, Catherine Clelland, Karen Duff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3270029?pdf=render

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http://europepmc.org/articles/PMC3270029?pdf=render

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