Thermoresponsive sol-gel improves ocular bioavailability of Dipivefrin hydrochloride and potentially reduces the elevated intraocular pressure in vivo

Thermoresponsive sol-gel improves ocular bioavailability of Dipivefrin hydrochloride and potentially reduces the elevated intraocular pressure in vivo

The present study involves the development of Dipivefrin hydrochloride (DV) containing Poloxamers (P407 and P188)-Carbopol-934 (CP) based thermoresponsive-gels for the management of elevated intraocular pressure (IOP). Optimal formulation was evaluated for gelation temperature (Tgel), physicochemica...

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Bibliographic Details
Main Authors: Musaed Alkholief, Mohd Abul Kalam, Aliyah Almomen, Abdullah Alshememry, Aws Alshamsan
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Saudi Pharmaceutical Journal
Subjects:
Thermoresponsive
Sol-gel
Dipivefrin
Poloxamers
Ocular
Intraocular-pressure
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016420301523

Internet

http://www.sciencedirect.com/science/article/pii/S1319016420301523

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