Aspirin and 5-Aminoimidazole-4-carboxamide Riboside Attenuate Bovine Ephemeral Fever Virus Replication by Inhibiting BEFV-Induced Autophagy

Aspirin and 5-Aminoimidazole-4-carboxamide Riboside Attenuate Bovine Ephemeral Fever Virus Replication by Inhibiting BEFV-Induced Autophagy

Recent study in our laboratory has demonstrated that BEFV-induced autophagy via activation of the PI3K/Akt/NF-κB and Src/JNK pathways and suppression of the PI3K-AKt-mTORC1 pathway is beneficial for virus replication. In the current study, we found that both aspirin and 5-aminoimidazole-4-carboxamid...

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Bibliographic Details
Main Authors: Hsu-Hung Tseng, Wei-Ru Huang, Ching-Yuan Cheng, Hung-Chuan Chiu, Tsai-Ling Liao, Brent L. Nielsen, Hung-Jen Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
5-aminoimidazole-4-carboxamide-1-β-riboside
aspirin
PI3K/Akt/NF-kB
autophagy
bovine ephemeral fever virus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.556838/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.556838/full

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