The Perfect Condition for the Rising of Superbugs: Person-to-Person Contact and Antibiotic Use Are the Key Factors Responsible for the Positive Correlation between Antibiotic Resistance Gene Diversity and Virulence Gene Diversity in Human Metagenomes

The Perfect Condition for the Rising of Superbugs: Person-to-Person Contact and Antibiotic Use Are the Key Factors Responsible for the Positive Correlation between Antibiotic Resistance Gene Diversity and Virulence Gene Diversity in Human Metagenomes

Human metagenomes with a high diversity of virulence genes tend to have a high diversity of antibiotic-resistance genes and vice-versa. To understand this positive correlation, we simulated the transfer of these genes and bacterial pathogens in a community of interacting people that take antibiotics...

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Bibliographic Details
Main Authors: Célia P. F. Domingues, João S. Rebelo, Joël Pothier, Francisca Monteiro, Teresa Nogueira, Francisco Dionisio
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Antibiotics
Subjects:
antibiotic resistance
virulence
microbiome
metagenomics
human gut
computer simulation
Online Access:https://www.mdpi.com/2079-6382/10/5/605

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https://www.mdpi.com/2079-6382/10/5/605

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