Review: Therapeutic options for continuous dopaminergic stimulation in Parkinson's disease

Treatment of Parkinson's disease aims to replace dopaminergic transmission at striatal synapses. In the normal state, nigral neurons fire continuously, exposing striatal dopamine receptors to relatively constant levels of dopamine. In the disease state, periodic dosing and the short half-life o...

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Bibliographic Details
Main Authors: O.K. Sujith, Carol Lane
Format: Article
Language:English
Published: SAGE Publishing 2009-03-01
Series:Therapeutic Advances in Neurological Disorders
Online Access:https://doi.org/10.1177/1756285608101378