Activation of 2' 5'-oligoadenylate synthetase by stem loops at the 5'-end of the West Nile virus genome.

Activation of 2' 5'-oligoadenylate synthetase by stem loops at the 5'-end of the West Nile virus genome.

West Nile virus (WNV) has a positive sense RNA genome with conserved structural elements in the 5' and 3' -untranslated regions required for polyprotein production. Antiviral immunity to WNV is partially mediated through the production of a cluster of proteins known as the interferon stimu...

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Bibliographic Details
Main Authors: Soumya Deo, Trushar R Patel, Edis Dzananovic, Evan P Booy, Khalid Zeid, Kevin McEleney, Stephen E Harding, Sean A McKenna
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3961380?pdf=render

Internet

http://europepmc.org/articles/PMC3961380?pdf=render

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