Increasing the safety and efficacy of chimeric antigen receptor T cell therapy

Increasing the safety and efficacy of chimeric antigen receptor T cell therapy

Abstract Chimeric antigen receptor (CAR) T cell therapy is a promising cancer treatment that has recently been undergoing rapid development. However, there are still some major challenges, including precise tumor targeting to avoid off-target or “on-target/off-tumor” toxicity, adequate T cell infilt...

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Bibliographic Details
Main Authors: Hua Li, Yangbing Zhao
Format: Article
Language:English
Published: SpringerOpen 2017-04-01
Series:Protein & Cell
Subjects:
chimeric antigen receptors
cancer adoptive immunotherapy
T lymphocytes
gene therapy
gene editing
Online Access:http://link.springer.com/article/10.1007/s13238-017-0411-9

Internet

http://link.springer.com/article/10.1007/s13238-017-0411-9

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