Effects of Shear Stress on Production of FVIII and vWF in a Cell-Based Therapeutic for Hemophilia A

Effects of Shear Stress on Production of FVIII and vWF in a Cell-Based Therapeutic for Hemophilia A

Microfluidic technology enables recapitulation of organ-level physiology to answer pertinent questions regarding biological systems that otherwise would remain unanswered. We have previously reported on the development of a novel product consisting of human placental cells (PLC) engineered to overex...

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Bibliographic Details
Main Authors: Brady Trevisan, Alshaimaa Morsi, Julio Aleman, Martin Rodriguez, Jordan Shields, Diane Meares, Andrew M. Farland, Christopher B. Doering, H. Trent Spencer, Anthony Atala, Aleks Skardal, Christopher D. Porada, Graça Almeida-Porada
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
FVIII
vWF
microfluidics
gene therapy
mRNA
shear stress
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.639070/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.639070/full

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