Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?

Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?

Glutamatergic dysfunction is strongly implicated in schizophrenia and mood disorders. GluA1 knockout (KO) mice display schizophrenia- and depression-related abnormalities. Here, we asked whether GluA1 KO show mania-related abnormalities. KO were tested for behavior in approach/avoid conflict tests,...

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Bibliographic Details
Main Authors: Paul J. Fitzgerald, Chris Barkus, Michael Feyder, Lisa M. Wiedholz, Yi-Chyan Chen, Rose-Marie Karlsson, Rodrigo Machado-Vieira, Carolyn Graybeal, Trevor Sharp, Carlos Zarate, Judith Harvey-White, Jing Du, Rolf Sprengel, Peter Gass, David Bannerman, Andrew Holmes
Format: Article
Language:English
Published: Elsevier 2010-12-01
Series:Neurobiology of Disease
Subjects:
Glutamate
Mouse
Stress
Anxiety
Mania
Dopamine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110002603

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http://www.sciencedirect.com/science/article/pii/S0969996110002603

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