Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth

Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth

Abstract The endogenous cholinergic system plays a key role in neuronal cells, by suppressing neurite outgrowth and myelination and, in some cancer cells, favoring tumor growth. Platinum compounds are widely used as part of first line conventional cancer chemotherapy; their efficacy is however limit...

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Bibliographic Details
Main Authors: Olivier Cerles, Tânia Cristina Gonçalves, Sandrine Chouzenoux, Evelyne Benoit, Alain Schmitt, Nathaniel Edward Bennett Saidu, Niloufar Kavian, Christiane Chéreau, Camille Gobeaux, Bernard Weill, Romain Coriat, Carole Nicco, Frédéric Batteux
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Acta Neuropathologica Communications
Subjects:
Benztropine
Oxaliplatin
Peripheral neuropathies
Muscarinic receptors
Myelin
Online Access:http://link.springer.com/article/10.1186/s40478-019-0657-y

Internet

http://link.springer.com/article/10.1186/s40478-019-0657-y

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