Anti-CD19 CARs displayed at the surface of lentiviral vector particles promote transduction of target-expressing cells

Anti-CD19 CARs displayed at the surface of lentiviral vector particles promote transduction of target-expressing cells

Recently, a rare type of relapse was reported upon treating a B cell acute lymphoblastic leukemia (B-ALL) patient with anti-CD19 chimeric antigen receptor (CAR)-T cells caused by unintentional transduction of residual malignant B cells (CAR-B cells). We show that anti-CD19 and anti-CD20 CARs are pre...

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Bibliographic Details
Main Authors: Nicole Cordes, Carolin Kolbe, Dominik Lock, Tatjana Holzer, Deborah Althoff, Daniel Schäfer, Franziska Blaeschke, Bettina Kotter, Sandra Karitzky, Claudia Rossig, Toni Cathomen, Tobias Feuchtinger, Iris Bürger, Mario Assenmacher, Thomas Schaser, Andrew D. Kaiser
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
CAR-T
CAR-B
immunotherapy
lentiviral vector
CAR display
CAR-T cell resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000280

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http://www.sciencedirect.com/science/article/pii/S2329050121000280

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