Undifferentiated Wharton's Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T-Cell-Mediated Autoimmunity in Nonobese Diabetic Mice

Undifferentiated Wharton's Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T-Cell-Mediated Autoimmunity in Nonobese Diabetic Mice

Type 1 diabetes mellitus is caused by T-cell-mediated autoimmune destruction of pancreatic β-cells. Systemic administration of mesenchymal stem cells (MSCs) brings about their incorporation into a variety of tissues with immunosuppressive effects, resulting in regeneration of pancreatic islets. We p...

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Bibliographic Details
Main Authors: Pei-Jiun Tsai, Hwai-Shi Wang, Gu-Jiun Lin, Shu-Cheng Chou, Tzu-Hui Chu, Wen-Ting Chuan, Ying-Jui Lu, Ying-Jui Weng, Cheng-Hsi Su, Po-Shiuan Hsieh, Huey-Kang Sytwu, Chi-Hung Lin, Tien-Hua Chen M.D., Jia-Fwu Shyu M.D., Ph.D.
Format: Article
Language:English
Published: SAGE Publishing 2015-08-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368914X683016

Internet

https://doi.org/10.3727/096368914X683016

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