Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

Summary: Histone methyltransferase KMT2D harbors frequent loss-of-function somatic point mutations in several tumor types, including melanoma. Here, we identify KMT2D as a potent tumor suppressor in melanoma through an in vivo epigenome-focused pooled RNAi screen and confirm the finding by using a g...

Full description

Bibliographic Details
Main Authors: Mayinuer Maitituoheti, Emily Z. Keung, Ming Tang, Liang Yan, Hunain Alam, Guangchun Han, Anand K. Singh, Ayush T. Raman, Christopher Terranova, Sharmistha Sarkar, Elias Orouji, Samir B. Amin, Sneha Sharma, Maura Williams, Neha S. Samant, Mayura Dhamdhere, Norman Zheng, Tara Shah, Amiksha Shah, Jacob B. Axelrad, Nazanin E. Anvar, Yu-Hsi Lin, Shan Jiang, Edward Q. Chang, Davis R. Ingram, Wei-Lien Wang, Alexander Lazar, Min Gyu Lee, Florian Muller, Linghua Wang, Haoqiang Ying, Kunal Rai
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
KMT2D
chromatin
epigenetics
melanoma
RNAi screen
IGFBP5
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312821

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720312821

Similar Items