Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny.

Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny.

The development of a megakaryocyte lineage specific Cre deleter, using the Pf4 (CXCL4) promoter (Pf4-Cre), was a significant step forward in the specific analysis of platelet and megakaryocyte cell biology. However, in the present study we have employed a sensitive reporter-based approach to demonst...

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Bibliographic Details
Main Authors: Simon D J Calaminus, Amelie V Guitart, Amy Sinclair, Hannah Schachtner, Steve P Watson, Tessa L Holyoake, Kamil R Kranc, Laura M Machesky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3531453?pdf=render

Internet

http://europepmc.org/articles/PMC3531453?pdf=render

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