Hydroxychloroquine reverses the prothrombotic state in a mouse model of antiphospholipid syndrome: Role of reduced inflammation and endothelial dysfunction.

Hydroxychloroquine reverses the prothrombotic state in a mouse model of antiphospholipid syndrome: Role of reduced inflammation and endothelial dysfunction.

Antiphospholipid antibodies (aPL) promote endothelial dysfunction, inflammation and procoagulant state. We investigated the effect of hydroxychloroquine (HCQ) on prothrombotic state and endothelial function in mice and in human aortic endothelial cells (HAEC). Human aPL were injected to C57BL/6 mice...

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Bibliographic Details
Main Authors: Sébastien Miranda, Paul Billoir, Louise Damian, Pierre Alain Thiebaut, Damien Schapman, Maelle Le Besnerais, Fabienne Jouen, Ludovic Galas, Hervé Levesque, Véronique Le Cam-Duchez, Robinson Joannides, Vincent Richard, Ygal Benhamou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0212614

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https://doi.org/10.1371/journal.pone.0212614

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